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Glucotect™
Natural Blood Sugar Support

Regular Price, 60-day supply (120 capsules):
$45.99
Member Price (GoldPLUS or higher):
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$41.39
Case of 12 (15% savings):
$469.10
Make this a Recurring Order. Choose the recurring order option in the dropdown above and every 60 days we will automatically bill and ship you another 60-day supply. Shipping will be charged for the initial shipment. Subsequent recurring order shipments to addresses within the contiguous U.S. will ship for FREE!

  • 100% vegan

  • Cinnamon extract, which may support healthy blood glucose levels

  • L-Carnitine, which contributes to insulin sensitivity

  • Thiamin and chromium, which help produce energy from glucose

  • Extracts of white mulberry leaf, banaba leaf, gymnema leaf and fenugreek seed

Caution: If pregnant, nursing or on medication, consult with your healthcare practitioner.

My Nutritarian eating style, as described in The End of Diabetes, helps to normalize blood glucose levels by focusing on antioxidant-rich, high fiber, whole plant foods having only modest glycemic effects. I designed Glucotect™ as a supplement to accompany a Nutritarian lifestyle, to provide extra assistance if needed for those who are striving to achieve healthy blood glucose levels. Glucotect™ promotes healthy glucose levels safely and naturally, using a carefully selected combination of essential micronutrients and plant extracts.

Cinnamon extract
Supplemental cinnamon powder and cinnamon extracts have been tested in numerous studies for their ability to normalize fasting blood glucose.1,2 Cinnamon extract, as utilized in Glucotect™, has been studied in human trials, and there is evidence that this extract supports healthy blood glucose levels.3-5 The bark of cinnamon trees contains phytochemicals that research suggests enhance insulin signaling and facilitate cellular glucose uptake and storage .6-9

Multiple species of evergreen trees belong to the cinnamon family. The most common culinary cinnamon is Cassia cinnamon, and this is the cinnamon powder that has most often been used in glucose-management trials. The major drawback to using a high dose of Cassia cinnamon is the presence of coumarin, a substance which may damage the liver. Powdered cinnamon supplements are known to contain amounts of coumarin that may approach the maximum recommended daily dose.1 Although no adverse effects have been reported in glucose-lowering trials, I have chosen not to use Cassia cinnamon in Glucotect™ as a safety precaution.10 Ceylon cinnamon, (“true” cinnamon) is preferable to Cassia for culinary uses because of its more complex flavor and the absence of coumarin; however, Ceylon cinnamon has not been adequately evaluated in human studies for its glucose-balancing effects.11 For the safest and most effective source of supplemental cinnamon, a purified cinnamon extract is utilized, designed to concentrate the effective phytochemicals and exclude the coumarin.

L-Carnitine
L-carnitine is an amino acid present in animal foods and synthesized in the human body from two other amino acids, lysine and methionine. L-carnitine is concentrated in skeletal and cardiac muscle, plays an important role in the chemical reactions of energy metabolism, and contributes to insulin sensitivity. Low carnitine levels can result in the accumulation of lipid metabolites during energy production, which is associated with insulin resistance.12-15

Thiamin
Thiamin is one of the B vitamins (vitamin B1) and plays an important role as a cofactor in the chemical reactions of glucose metabolism and insulin production. It is common for diabetics to excrete too much thiamin via the kidneys, and they are at risk of deficiency.16, 17 Thiamin deficiency can exacerbate diabetes symptoms, since thiamin is important for glucose metabolism and insulin production.18 Furthermore, thiamin deficiency over time may damage the arterial walls and promote the dangerous complications of diabetes, including neuropathy, nephropathy and retinopathy.16, 18, 19 Consequently, it is imperative for those with diabetes to maintain adequate thiamin levels; however, the amount obtained from foods and multivitamin supplements may not be enough. A higher dose of thiamin than that generally recommended of the Institute of Medicine is likely required by diabetics, to counteract the increased thiamin losses.20 High-dose thiamin supplements are available, but those excessive doses are not necessary on a Nutritarian program. A conservative dose of thiamin is included in Glucotect™, in order to prevent deficiency without unnecessary levels of supplementation.

Chromium
Chromium is an essential mineral, and similar to thiamin, it is an important cofactor in the chemical reactions that produce energy from glucose. In addition, chromium enhances insulin signaling, allowing insulin to efficiently transport glucose from the bloodstream into the body’s cells. The standard American diet, rich in refined carbohydrates, promotes chromium loss, and it is common for diabetics to have lower chromium levels than healthy individuals. High-dose chromium supplementation has been shown to reduce fasting blood glucose and HbA1C levels in diabetics.21, 22 However, switching to a Nutritarian eating style will help to normalize chromium intake and reduce chromium loss. Similar to thiamin, excessively high doses are not required to maintain adequacy and allow for the proper functioning of chromium in the body. A conservative dose of chromium is included in Glucotect™ as chromium picolinate, which is more absorbable than other forms.23 This level of supplementation is designed to protect against deficiency while avoiding excess.

Additional plant extracts

Glucotect™ contains extracts of white mulberry leaf, banaba leaf, gymnema leaf and fenugreek seed. The leaves of the mulberry tree are the preferred food of silkworms, while the berries are often eaten by humans. Banaba is a common ornamental tree grown in Asia. Gymnema is a large, woody plant that grows indigenously in India, Africa, and Australia. Fenugreek is a deep yellow seed used as a spice in the cuisines of India and North Africa. Although effective doses have not been established and further research is necessary, preliminary studies suggest that these plant extracts may have glucose-balancing properties.24-38

Caution: If pregnant, nursing or on medication, consult with your healthcare practitioner.

Suggested Use:
Take 1-2 capsules three times daily. Best taken with food.

References:
1. Davis PA, Yokoyama W: Cinnamon intake lowers fasting blood glucose: meta-analysis. J Med Food 2011, 14:884-889.
2. Akilen R, Tsiami A, Devendra D, et al: Cinnamon in glycaemic control: Systematic review and meta analysis. Clin Nutr 2012, 31:609-615.
3. Ziegenfuss TN, Hofheins JE, Mendel RW, et al: Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women. J Int Soc Sports Nutr 2006, 3:45-53.
4. Khan A, Safdar M, Ali Khan MM, et al: Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003, 26:3215-3218.
5. Mang B, Wolters M, Schmitt B, et al: Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest 2006, 36:340-344.
6. Nahas R, Moher M: Complementary and alternative medicine for the treatment of type 2 diabetes. Can Fam Physician 2009, 55:591-596.
7. Imparl-Radosevich J, Deas S, Polansky MM, et al: Regulation of PTP-1 and insulin receptor kinase by fractions from cinnamon: implications for cinnamon regulation of insulin signalling. Horm Res 1998, 50:177-182.
8. Jarvill-Taylor KJ, Anderson RA, Graves DJ: A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr 2001, 20:327-336.
9. Anderson RA, Broadhurst CL, Polansky MM, et al: Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J Agric Food Chem 2004, 52:65-70.
10. Qin B, Panickar KS, Anderson RA: Cinnamon: potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes. J Diabetes Sci Technol 2010, 4:685-693.
11. Ranasinghe P, Jayawardana R, Galappaththy P, et al: Efficacy and safety of 'true' cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis. Diabet Med 2012, 29:1480-1492.
12. Ringseis R, Keller J, Eder K: Role of carnitine in the regulation of glucose homeostasis and insulin sensitivity: evidence from in vivo and in vitro studies with carnitine supplementation and carnitine deficiency. Eur J Nutr 2012, 51:1-18.
13. Mingorance C, Rodriguez-Rodriguez R, Justo ML, et al: Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders. Vasc Health Risk Manag 2011, 7:169-176.
14. Derosa G, Maffioli P, Salvadeo SA, et al: Sibutramine and L-carnitine compared to sibutramine alone on insulin resistance in diabetic patients. Intern Med 2010, 49:1717-1725.
15. Molfino A, Cascino A, Conte C, et al: Caloric restriction and L-carnitine administration improves insulin sensitivity in patients with impaired glucose metabolism. JPEN J Parenter Enteral Nutr 2010, 34:295-299.
16. Thornalley PJ: The potential role of thiamine (vitamin B1) in diabetic complications. Curr Diabetes Rev 2005, 1:287-298.
17. Thornalley PJ, Babaei-Jadidi R, Al Ali H, et al: High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease. Diabetologia 2007, 50:2164-2170.
18. Page GL, Laight D, Cummings MH: Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease. Int J Clin Pract 2011, 65:684-690.
19. Wong CY, Qiuwaxi J, Chen H, et al: Daily intake of thiamine correlates with the circulating level of endothelial progenitor cells and the endothelial function in patients with type II diabetes. Mol Nutr Food Res 2008, 52:1421-1427.
20. Vindedzis SA, Stanton KG, Sherriff JL, et al: Thiamine deficiency in diabetes - is diet relevant? Diab Vasc Dis Res 2008, 5:215.
21. Kozlovsky AS, Moser PB, Reiser S, et al: Effects of diets high in simple sugars on urinary chromium losses. Metabolism 1986, 35:515-518.
22. Via M: The malnutrition of obesity: micronutrient deficiencies that promote diabetes. ISRN Endocrinol 2012, 2012:103472.
23. Lamson DW, Plaza SM: The safety and efficacy of high-dose chromium. Altern Med Rev 2002, 7:218-235.
24. Mudra M, Ercan-Fang N, Zhong L, et al: Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 2007, 30:1272-1274.
25. Andallu B, Suryakantham V, Lakshmi Srikanthi B, et al: Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta 2001, 314:47-53.
26. Fukushima M, Matsuyama F, Ueda N, et al: Effect of corosolic acid on postchallenge plasma glucose levels. Diabetes Res Clin Pract 2006, 73:174-177.
27. Judy WV, Hari SP, Stogsdill WW, et al: Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study. J Ethnopharmacol 2003, 87:115-117.
28. Stohs SJ, Miller H, Kaats GR: A review of the efficacy and safety of banaba (Lagerstroemia speciosa L.) and corosolic acid. Phytother Res 2012, 26:317-324.
29. Leach MJ: Gymnema sylvestre for diabetes mellitus: a systematic review. J Altern Complement Med 2007, 13:977-983.
30. Kumar SN, Mani UV, Mani I: An open label study on the supplementation of Gymnema sylvestre in type 2 diabetics. J Diet Suppl 2010, 7:273-282.
31. Al-Romaiyan A, Liu B, Asare-Anane H, et al: A novel Gymnema sylvestre extract stimulates insulin secretion from human islets in vivo and in vitro. Phytother Res 2010, 24:1370-1376.
32. Sauvaire Y, Petit P, Broca C, et al: 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion. Diabetes 1998, 47:206-210.
33. Cefalu WT, Stephens JM, Ribnicky DM: Diabetes and Herbal (Botanical) Medicine. In Herbal Medicine: Biomolecular and Clinical Aspects 2nd edition. Edited by Benzie IFF, Wachtel-Galor S. Boca Raton, FL: CRC Press; 2011
34. Zhou J, Chan L, Zhou S: Trigonelline: a plant alkaloid with therapeutic potential for diabetes and central nervous system disease. Curr Med Chem 2012, 19:3523-3531.
35. Moorthy R, Prabhu KM, Murthy PS: Anti-hyperglycemic compound (GII) from fenugreek (Trigonella foenum-graecum Linn.) seeds, its purification and effect in diabetes mellitus. Indian J Exp Biol 2010, 48:1111-1118.
36. Ajabnoor MA, Tilmisany AK: Effect of Trigonella foenum graceum on blood glucose levels in normal and alloxan-diabetic mice. J Ethnopharmacol 1988, 22:45-49.
37. Lu FR, Shen L, Qin Y, et al: Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus. Chin J Integr Med 2008, 14:56-60.
38. van Dijk AE, Olthof MR, Meeuse JC, et al: Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance. Diabetes Care 2009, 32:1023-1025.

The products and statements made about specific products on this web site have not been evaluated by the United States Food and Drug Administration (FDA) and are not intended to diagnose, treat, cure or prevent disease. All information provided on this web site or any information contained on or in any product label or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this web site for diagnosis or treatment of any health problem. Always consult with a healthcare professional before starting any new vitamins, supplements, diet, or exercise program, before taking any medication, or if you have or suspect you might have a health problem.
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