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Powerful Disease Protection from Pomegranate

 Pomegranate was one of the earliest cultivated fruits, and the fruit has been prominent throughout history in art, culture, and religion, from the story of the seasons in Greek mythology to Romeo and Juliet to the Bible.1,2 Pomegranate is ubiquitous in Middle Eastern cooking and its super food status and unique flavor and texture has made it increasingly popular in the U.S. in recent years. A pomegranate contains hundreds of tiny, crisp arils; each aril is a seed encased in a juicy pulp, a tasty mix of sweet and tart flavors.

Pomegranate contains a unique and powerful antioxidant called punicalagin, the most abundant antioxidant in pomegranate, responsible for more than half of the antioxidant activity of pomegranate juice.3 Pomegranate juice has been analyzed to have greater antioxidant capacity than red wine, grape juice, cranberry juice, green tea or acai juice;4 drinking pomegranate juice measurably reduces oxidative stress in healthy humans.5 Much research has shown that pomegranate’s potent antioxidant capacity provides protection against heart disease, cancer and cognitive impairment.

Anti-cancer:

  • Pomegranate has anti-inflammatory effects that may protect against cancer and other chronic diseases.6,7
  • Pomegranate has anti-angiogenic properties, meaning that pomegranate may help to prevent growing tumors from acquiring a blood supply, preventing those tumors from receiving the nutrients that would allow them to grow larger.8-10
  • Pomegranate is one of the few foods (mushrooms are another) that contain natural aromatase inhibitors — this means that they inhibit the production of estrogen, which can reduce breast cancer risk.11
  • In men after treatment for prostate cancer, two studies have shown that pomegranate juice or supplements slowed the increase in PSA.12

Cardioprotective:

  • Pomegranate phytochemicals reduce LDL oxidation (a contributor to atherosclerotic plaque development).13
  • Pomegranate phytochemicals have blood pressure-reducing properties.14,15
  • In a study of patients with severe carotid artery blockages, after one ounce of pomegranate juice daily for one year, there was a 30 percent reduction in atherosclerotic plaque. In striking contrast, in the participants who did not take the pomegranate juice atherosclerotic plaque increased by 9 percent.13

Memory and brain function:

  • Pomegranate supplements taken before and after surgery prevented the postoperative memory dysfunction associated with coronary artery bypass or heart valve surgery.16
  • In those with mild memory complaints, those drinking pomegranate juice daily performed better on a memory task compared to placebo and displayed increased brain activation measured by functional MRI.17

Removing the edible arils from the pomegranate is easy when you know how to do it. The easiest way is to cut it around the diameter, split it into two and then pound the back with the back of a large serving spoon. The flavor and health benefits of pomegranate make the effort well worth it. Enjoy fresh pomegranates now that they are in season, and store some arils in the freezer to get the health benefits of pomegranate all year round.


References:

1. Wolf B: Pomegranates: Jewels In The Fruit Crown. 2006.
2. Langley P: Why a pomegranate? BMJ 2000, 321:1153-1154.
3. Heber D: Pomegranate Ellagitannins. In Herbal Medicine: Biomolecular and Clinical Aspects 2nd Edition. Edited by Benzie IFF, Wachtel-Galor, S.: CRC Press; 2011
4. Seeram NP, Aviram M, Zhang Y, et al: Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States. J Agric Food Chem 2008, 56:1415-1422.
5. Aviram M, Dornfeld L, Rosenblat M, et al: Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am J Clin Nutr 2000, 71:1062-1076.
6. Panchal SK, Ward L, Brown L: Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. Eur J Nutr 2012.
7. Adams LS, Seeram NP, Aggarwal BB, et al: Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. Journal of Agricultural and Food Chemis ry 2006, 54:980-985.
8. Khan N, Afaq F, Kweon MH, et al: Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Cancer Res 2007, 67:3475-3482.
9. Toi M, Bando H, Ramachandran C, et al: Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo. Angiogenesis 2003, 6:121-128.
10. Sartippour MR, Seeram NP, Rao JY, et al: Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo. Int J Oncol 2008, 32:475-480.
11. Adams LS, Zhang Y, Seeram NP, et al: Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Cancer Prev Res (Phila) 2010, 3:108-113.
12. Kroeger N, Belldegrun AS, Pantuck AJ: Pomegranate Extracts in the Management of Men's Urologic Health: Scientific Rationale and Preclinical and Clinical Data. Evid Based Complement Alternat Med 2013, 2013:701434.
13. Aviram M, Rosenblat M, Gaitini D, et al: Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004, 23:423-433.
14. Aviram M, Dornfeld L: Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001, 158:195-198.
15. Aviram M, Volkova N, Coleman R, et al: Pomegranate phenolics from the peels, arils, and flowers are antiatherogenic: studies in vivo in atherosclerotic apolipoprotein e-deficient (E 0) mice and in vitro in cultured macrophages and lipoproteins. Journal of Agricultural and Food Chemis ry 2008, 56:1148-1157.
16. Ropacki SA, Patel SM, Hartman RE: Pomegranate Supplementation Protects against Memory Dysfunction after Heart Surgery: A Pilot Study. Evid Based Complement Alternat Med 2013, 2013:932401.
17. Bookheimer SY, Renner BA, Ekstrom A, et al: Pomegranate juice augments memory and FMRI activity in middle-aged and older adults with mild memory complaints. Evid Based Complement Alternat Med 2013, 2013:946298.

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